发明名称 |
METHOD FOR PREPARING PHYSIOLOGICALLY ACTIVE POLYPEPTIDE COMPLEX |
摘要 |
<p>A method for preparing a conjugate of a physiologically active polypeptide and a non-peptide polymer by linking physiologically active polypeptide with non-peptide polymer through a covalent bond using an organic solvent is provided. A method for preparing a physiologically active polypeptide complex by linking the conjugate with a carrier is provided. The complex shows improved in vivo duration and stability of the physiologically active polypeptide. The method can prepare the conjugate at a lower production cost, and the resulting conjugate shows an extension of in vivo activity at a relatively high level and significantly increase in the blood half-life.</p> |
申请公布号 |
EP2773672(A1) |
申请公布日期 |
2014.09.10 |
申请号 |
EP20120845690 |
申请日期 |
2012.11.02 |
申请人 |
HANMI SCIENCE CO., LTD. |
发明人 |
KIM, DAE JIN;JANG, MYUNG HYUN;KIM, SEUNG SU;LEE, JONG SOO;CHOI, JAE HYUK;KWON, SE CHANG |
分类号 |
C07K17/10;C07K1/18;C07K17/08 |
主分类号 |
C07K17/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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