Thyroid hormone β receptor agonist

摘要

Provided is a heterocyclic derivative showing a thyroid hormone β receptor agonist action, which is effective for the prophylaxis or treatment of the diseases relating to the action. A compound represented by the formula [I]:;
wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, and a medicament containing the compound as an active ingredient.

主权项

1. A compound represented by the formula: wherein A is optionally substituted alkyl, optionally substituted carbocyclic group, optionally substituted aryl, optionally substituted heterocyclic group, optionally substituted heteroaryl, optionally substituted amino, or optionally substituted carbamoyl, X is optionally substituted methylene, —O— or —S—, Q is C—R4, L1 is single bond, methylene, —CH═CH—, —O—, —CO—, —NR11—, —NR11CO—, —CONR11—, —CH2NR11— or —S—, L2 is single bond, —CR6R7—, or divalent heterocyclic group, R1 and R2 are the same or different and each is hydrogen, alkyl, alkenyl or halogen, R3 and R4 are the same or different and each is hydrogen, alkyl, alkoxy, cyano or halogen, R1 and R3 are optionally bonded to form carbocycle or heterocycle, R5 is a carboxyl group, an alkoxycarbonyl group or bioisosteric group of carboxyl group, wherein the bioisosteric group is selected from the group consisting of the following formulae: wherein R51 and R52 are the same or different and each is alkyl optionally substituted by alkanoyloxy or alkoxycarbonyl, or hydrogen, R51 and R52 may be bonded to form heterocycle optionally substituted by aryl optionally substituted by halogen, and R53 and R54 are the same or different and each is alkyl or hydrogen, R6 and R7 are the same or different and each is hydrogen, optionally substituted alkyl or halogen, or R6 and R7 are bonded to form cycloalkane or heterocycle, R8 is hydroxy, alkanoylamino or alkylsulfonylamino, R9 and R10 are the same or different and each is hydrogen, alkyl or halogen, and R11 is hydrogen or alkyl, or a pharmacologically acceptable salt thereof.