Biomarkers for Painful Intervertebral Discs and Methods of Use Thereof

摘要

The present disclosure provides methods of diagnosing painful intervertebral discs. The present disclosure also provides methods of treating a painful intervertebral disc.

主权项

1. A method of identifying a painful intervertebral disc, the method comprising assaying for an expression level of a gene product of at least one pain indicator gene selected from COL2A, COL9A3, AGC1, DCN, MMP3, MMP13, TIMP1, TIMP3, CD44, HIF1, IL8, IL1R, PLA2, TSG6, MMP9, Col1A1, Col3, BMP7, TNF-α, IL1β, PGE2, HIF1A, and ADAMTS5,
wherein a decreased expression level of a gene product selected from COL2A, COL9A3, AGC1, DCN, MMP3, MMP13, TIMP1, TIMP3, CD44, HIF1, IL8, IL1R, PLA2, TSG6, MMP9, Col1A1, and Col3 in an intervertebral disc tissue, compared to a normal control value, indicates that the intervertebral disc is painful, and wherein an increased expression level of a gene product selected from BMP7, TNF-α, IL1β, PGE2, HIF1A, and ADAMTS5 in an intervertebral disc tissue, compared to a normal control value, indicates that the intervertebral disc is painful.