发明名称 |
Solid dispersions containing an apoptosis-promoting agent |
摘要 |
A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound, e.g., ABT-263, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer. |
申请公布号 |
AU2010258943(B2) |
申请公布日期 |
2014.03.13 |
申请号 |
AU20100258943 |
申请日期 |
2010.06.08 |
申请人 |
ABBVIE INC. |
发明人 |
SCHMITT, ERIC A.;TONG, PING;HEEMSTRA, KATHERINE;FISCHER, CRISTINA M.;WU, HUAILIANG;MILLER, JONATHAN MARK;LI, YANXIA;LAFOUNTAINE, JUSTIN S. |
分类号 |
A61K9/00;A61K9/14;A61K31/5377;A61K33/04;A61P35/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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