发明名称 |
Drug Delivery Nanocarriers Targeted by Landscape Phage |
摘要 |
A targeted drug delivery nanocarrier and a method of forming the same is disclosed herein. The targeted drug delivery nanocarrier includes a plurality of amphipathic molecules forming a carrier particle having a plurality of drug molecules contained therein. A targeted landscape phage protein assembly is complexed to the carrier particle preferably using the unique method disclosed herein. The targeted landscape phage protein assembly displays a binding peptide that is selected to specifically and selectively bind to a target site. The method for forming targeted drug delivery nanocarriers includes the steps of obtaining a plurality of bacteriophage displaying a binding peptide for a desired target site, treating the bacteriophage with a denaturing agent, mixing the treated bacteriophage with a plurality of carrier particles and purifying the mixture to obtain a plurality of targeted drug delivery nanocarriers.
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申请公布号 |
US2012141591(A1) |
申请公布日期 |
2012.06.07 |
申请号 |
US201213369007 |
申请日期 |
2012.02.08 |
申请人 |
PETRENKO VALERY A.;AUBURN UNIVERSITY |
发明人 |
PETRENKO VALERY A. |
分类号 |
A61K9/51;A61K31/337;A61K31/704;A61K31/7088;A61P35/00;B82Y5/00 |
主分类号 |
A61K9/51 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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