摘要 |
The invention provides a process for preparing a conjugate of a S.aurens type 5 or type 8 capsular polysaccharide and a carrier molecule, comprising the steps of: (a) depolymerising the capsular polysaccharide, to give a polysaccharide fragment; (b) oxidising the fragment in order to introduce an aldehyde group into at least one saccharide residue in the fragment, to give an oxidised saccharide residue; and (c) coupling the oxidised saccharide residue to a carrier molecule via the aldehyde group, thereby giving the conjugate. The coupling in step (c) may be direct, or may be via a linker molecule. The invention also provides a conjugate obtained or obtainable by this process. |
申请人 |
NOVARTIS AG;BERTI, FRANCESCO;COSTANTINO, PAOLO;ROMANO, MARIA, ROSARIA |
发明人 |
BERTI, FRANCESCO;COSTANTINO, PAOLO;ROMANO, MARIA, ROSARIA |