Medical uses of a selective androgen receptor modulator

摘要

Selective androgen receptor modulator (SARM) compounds having the formula (II):
wherein
Z
XisO; is NO 2 , CN, COR, or CONHR;
Y
is I, CF 3 , CH 3 , H, Br, Cl, F or Sn(R) 3 ;
R
is an alkyl, aryl, phenyl, alkenyl, haloalkyl, haloalkenyl, halogen or OH; and
Q
is C N . These compounds may be used in treating a subject having:
a bone-related disorder, such as osteoporosis, osteopenia, increased bone resorption, bone fracture, bone frailty, loss of bone mineral density (BMD);
a muscle wasting disorder, such as muscular dystrophy, a muscular atrophy, X-linked spinal-bulbar muscular atrophy (SBMA), a cachexia, sarcopenia, or a cardiomyopathy; hypercholesterolemia;
obesity or diabetes associated with a metabolic syndrome such as a hormonal imbalance, disorder, or disease;
or may be used in:
promoting or speeding recovery following a surgical procedure; and
promoting or suppressing spermatogenesis in a male subject.