ANTI-ANGIOGENIC COMPOSITION COMPRISING MICROBIAL BIOCONVERSION BIOMATERIALS OF ANGELICA GIGAS AND ZIZYPHUS JUJUBA PRODUCED BY ASPERGILLUS USAMII VAR. SHIROUSAMII

摘要

PURPOSE: A composition containing bioconversion biomaterial of Angelica gigas Naka and Zizyphus jujuba var. inermis Rehder for suppressing angiogenesis is provided to suppress MMP(matrix metalloproteinase) activation, vascular endothelial cell migration and tube formulation. CONSTITUTION: An agent for anti-angiogenesis contains bioconversion biomaterials of Angelica gigas Naka and Zizyphus jujuba var. inermis Rehder produced by Aspergillus usamii var. shirousamii. A pharmaceutical composition for preventing and treating angiogenesis-relating diseases contains the bioconversion biomaterial. The daily dose of the composition is 0.1~100mg/kg once to three times a day. A method for producing the bioconversion biomaterial of the Angelica gigas Naka and Zizyphus jujuba var. inermis Rehder comprises: a step of culturing Aspergillus usamii var. shirousamii and collecting cells by centrifuging; a step of crushing the cells to obtain crude microorganism enzyme; a step of performing thermal extraction; a step of reacting the extract with crude enzyme liquid; and a step of sterilizing at 95°C for 30 minutes using 0.22 of filter.