METHOD AND COMPOSITION FOR SPECIFIC COAGULATION OF BLOOD CIRCULATORY SYSTEM

摘要

PROBLEM TO BE SOLVED: To provide various compositions and methods for use in overcoming restriction of precedent techniques and achieving specific blood coagulation by providing new compositions and methods used for achieving specific coagulation, e.g., coagulation in tumor blood circulatory system, and controlled in adverse effects. SOLUTION: Ligands containing the following (a) and (b) are provided: (a) a first joint domain binding with disease cells, components of disease-related blood circulatory system or components of disease-related stroma; (b) a coagulation factor to which the first joint domain is bound to be active or a second joint domain binding with the coagulation factor. COPYRIGHT: (C)2009,JPO&INPIT