发明名称 |
Process for Forming Amorphous Atorvastatin |
摘要 |
A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin. |
申请公布号 |
US2008269314(A1) |
申请公布日期 |
2008.10.30 |
申请号 |
US20050666707 |
申请日期 |
2005.10.12 |
申请人 |
DEBETTEN-COURT ANTONE JOHN;ROSE PETER ROBERT;SHALAEV EVGENYI YUR EVICH;QUALLICH GEORGE JOSEPH;ZIEGLER CARL BERNARD |
发明人 |
DEBETTEN-COURT ANTONE JOHN;ROSE PETER ROBERT;SHALAEV EVGENYI YUR'EVICH;QUALLICH GEORGE JOSEPH;ZIEGLER CARL BERNARD |
分类号 |
A61K31/40 |
主分类号 |
A61K31/40 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|