PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO

摘要

Pyrazole derivatives of Formula (Ia) and pharmaceutical compositions ther eof that modulate the activity of the serotonin 5HT2A receptor. Formula (Ia) . Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of insomnia and related sleep disorders, platelet ag gregation, coronary artery disease, myocardial infarction, transient ischemi c attack, angina, stroke, atrial fibrillation, reducing the risk of blood cl ot formation, asthma or symptoms thereof, agitation or symptoms thereof, beh avioral disorders, drug induced psychosis, excitative psychosis, Gilles de I a Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic d isorders, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizop hrenia and related disorders, diabetic- related disorders, progressive multi focal leukoencephalopathy and the like. The present invention also relates t o the methods for the treatment of 5-HT2A serotonin receptor mediated disord ers in combination with other pharmaceutical agents administered separately or together.