摘要 |
The present invention relates to the use of a polyvalent synthetic compound comprising a support on which at least 3 pseudopeptide units are grafted, said compound being of formula (I), in which each X independently represents any amino acid; Y<SUB>1</SUB> and Y<SUB>2 </SUB>are selected independently from amino acids having a basic side chain; Z is selected from a proline, optionally substituted at ?, - or ..; a natural or non-natural N-alkylamino acid; a dialkylamino acid; a cyclic dialkylamino acid; pipecolic acid or a derivative thereof; n and i independently are 0 or 1; m is an integer between 0 and 3; k is an integer greater than or equal to 3; and ? represents a modified peptide bond which is significantly more resistant to at least one protease than a standard peptide bond, for preparing a medicament intended for treating a disease involving deregulation of cell proliferation and/or of angiogenesis, and preferably acting as a surface nucleolin ligand, or for treating inflammatory diseases. |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);COURTY, JOSE;HOVANESSIAN, ARA;BRIAND, JEAN PAUL;GUICHARD, GILLES;HAMMA, YAMINA |
发明人 |
COURTY, JOSE;HOVANESSIAN, ARA;BRIAND, JEAN PAUL;GUICHARD, GILLES;HAMMA, YAMINA |