摘要 |
<p>The present invention relates to a composition for diagnosing cancer metastasis comprising Ubiquitin C-terminal hydrolase-L1 (UCH-L1), a use of UCH-L1 for diagnosing cancer metastasis and a method for diagnosing cancer metastasis using the same; a composition for suppressing cancer metastasis comprising an inhibitor of UCH-L1, a use of an inhibitor of UCH-L1 for suppressing cancer metastasis and a method of suppressing cancer metastasis using the same; a composition for screening a cancer metastasis inhibitor comprising UCH-L1 protein, a use of UCH-L1 protein for screening a cancer metastasis inhibitor and a method of screening cancer metastasis inhibitor using the same; a composition for screening a cancer metastasis inhibitor comprising UCH-L1 gene, a use of UCH-L1 gene for screening a cancer metastasis inhibitor, a method of screening cancer metastasis inhibitor using the same. UCH-L1 is a key molecule to modulate cell migration including the cancer invasion according to their expression level. Thus, the monoclonal and polyclonal antibodies and the substrate of UCH-L1 can be used for diagnosis of cancer metastasis. Also, the cancer metastasis can be suppressed by inhibiting of the expression of UCH-L1 or activity of the enzyme, thus we can screen and develop an inhibitor of UCH-L1 and use it as an adjuvant drug for anticancer therapy.</p> |
申请人 |
EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION;SK CORPORATION;LEE, KONG JOO;KIM, HYUN JUNG;CHO, JEONG WOO;MAENG, CHEOL YOUNG;NAM, YOU KYUNG;LIM, SANG MI;KIM, YOUNG MEE |
发明人 |
LEE, KONG JOO;KIM, HYUN JUNG;CHO, JEONG WOO;MAENG, CHEOL YOUNG;NAM, YOU KYUNG;LIM, SANG MI;KIM, YOUNG MEE |