摘要 |
<p>The invention is directed to novel indole carboxamide derivatives. Specifically, theinvention is directed to compounds according to formula (1): where R1, R2, R3,U and V are defined below and to pharmaceutically acceptable salts thereof. Thecompounds of the invention are inhibitors of IKK2 and can be useful in the treatment ofdisorders associated with inappropriate IKK2 (also known as IKK a) activity, suchas rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease).Accordingly, the invention is further directed to pharmaceutical compositionscomprising a compound of the invention. The invention is still further directedto methods of inhibiting IKK2 activity and treatment of disorders associatedtherewith using a compound of the invention or a pharmaceutical composition comprisinga compound of the invention.</p> |