发明名称 |
REGULATION OF ONCOGENES BY MICRORNAS |
摘要 |
Naturally occurring miRNAs that regulate human oncogenes and methods of use therof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The compositions containing nucleic acids are administered to a patient in need of treatment or prophylaxis of at least one symptom or manifestation of cancer. In one embodiment, the compositions are administered in an effective amount to inhibit gene expression of one or more oncogenes. Methods for treatment or prevention of at least one symptom or manifestation of cancer are also described. |
申请公布号 |
WO2006028967(A3) |
申请公布日期 |
2007.02.22 |
申请号 |
WO2005US31327 |
申请日期 |
2005.09.02 |
申请人 |
YALE UNIVERSITY;SLACK, FRANK, J.;JOHNSON, STEVEN, M.;GROSSHANS, HELGE |
发明人 |
SLACK, FRANK, J.;JOHNSON, STEVEN, M.;GROSSHANS, HELGE |
分类号 |
A61K31/713;A61K48/00;A61P35/00;C12N15/113 |
主分类号 |
A61K31/713 |
代理机构 |
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