摘要 |
<p>FIELD: organic chemistry, medicine, biochemistry, pharmacy. ^ SUBSTANCE: invention relates to novel compounds of the formula (I): wherein R1 represents alkyl; R2 represents halogen atom, formyl, substituted or unsubstituted alkyl, hydroxyl, (C1-C6)-alkoxy-group, halogenalkyl; or R and R2 in common with atom to which they are bound form unsubstituted 5-7-membered structure of the formula: -CH2-(CH2)nS- wherein n = 1 or 2; R3 represents hydrogen atom, halogen atom or alkyl; R4 represents alkoxy-group or unsubstituted aryl or aryl substituted with halogen atom, (C1-C6)-alkyl, halogenated (C1-C6)-alkyl, (C1-C6)-alkoxy-group, (C1-C6)-alkylsulfonyl; R5 represents hydrogen atom, hydroxyl, alkyl, alkenyl or alkoxy-group; R6 represents hydrogen atom or alkyl; or R5 and R6 represent in common =O; X represents oxygen atom or -NR8 wherein R8 represents aryl substituted with halogen atom; m means a whole number in the range from 0 to 2, and its pharmaceutically acceptable salts. Also, invention relates to pharmaceutical compositions based on these compounds, method for treatment of diseases mediated by cyclooxygenase and to a method for inhibition of cyclooxygenase activity in cells. Invention provides preparing novel compounds possessing valuable biological effect. ^ EFFECT: valuable medicinal and biochemical properties of compounds and pharmaceutical compositions. ^ 11 cl, 98 ex</p> |