Methods for synthesizing organoboronic compounds and products thereof

摘要

Organoboronic acids, for example Cbz-(R)-Phe-(S)-Pro-(R)-Mpg-B(OH)₂, are made by hydrolysing their diethanolamine adducts under conditions which avoid substantial C-B bond breakage. The product acids are substantially free of degradation product derived from cleavage of the C-B bond thereof. The acids are used to make base addition salts thereof. The salts are formulated into anti-thrombotic pharmaceutical formulations.