THERAPEUTIC IMMUNIZATION OF HIV-INFECTED INDIVIDUALS

摘要

The present invention provides an improved method for eliciting a therapeuti c immune response in an individual infected with human immunodeficiency virus (~HIV~). The method comprises administering an adenoviral vaccine compositio n expressing an HIV antigen to an individual with controlled viremia. Immunization of infected individuals in this manner elicits a cellular- mediated immune response against the virus that is significant both in the level of the response and the breadth of the response. The therapeutic immun e response that ensues is capable of effectively maintaining low titers of vir us and, thus, offers the prospect of reducing individual dependency on antivira l therapy.