发明名称 |
Crystal forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one |
摘要 |
The instant invention describes a method for crystallizing (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.
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申请公布号 |
US2003208070(A1) |
申请公布日期 |
2003.11.06 |
申请号 |
US20030447690 |
申请日期 |
2003.05.29 |
申请人 |
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发明人 |
CROCKER LOUIS S.;KUKURA JOSEPH L.;THOMPSON ANDREW S.;STELMACH CHRISTINE;YOUNG STEVEN D. |
分类号 |
C07D265/18;(IPC1-7):C07D265/12 |
主分类号 |
C07D265/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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