METHODS OF DIAGNOSING AND COUNTERACTING ADOLESCENT IDIOPATHIC SCOLIOSIS

摘要

A method of diagnosing adolescent idiopathic scoliosis in a patient by determining the presence or absence of at least one mutation in melatonin signaling pathway and/or of at least one impairment in melatonin signaling in cells. A method of counteracting adolescent idiopathic scoliosis phenotype related to at least one melatonin signaling impairment in a cell by modulating melatonin signaling in the cell.