发明名称 |
Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions |
摘要 |
Methods for the identification of a drug target, wherein the drug target is a component of a signal transduction pathway, are provided. The methods are based, in part, on selection of a gene of therapeutic interest and determination of regulatory DNA sequences which regulate expression of the gene in a cell of interest, followed by reconstruction of signal transduction pathways which act on molecules which bind to the regulatory sequence. Also provided are methods for assessing potential pharmacological effects and/or side effects of an agent, based on the effect of the agent on the distribution and properties of accessible regions in cellular chromatin.
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申请公布号 |
US6610489(B2) |
申请公布日期 |
2003.08.26 |
申请号 |
US20010844265 |
申请日期 |
2001.04.27 |
申请人 |
SANGAMO BIOSCIENCES, INC. |
发明人 |
WOLFFE ALAN;URNOV FYODOR;GUSCHIN DMITRY;COLLINGWOOD TREVOR;LI XIAO-YONG;JOHNSTONE BRIAN |
分类号 |
C07K14/47;C12N15/10;C12N15/62;C12N15/63;C12N15/66;C12N15/67;C12Q1/68;G06F19/22;G06F19/28;(IPC1-7):C12Q1/68;G01N33/00 |
主分类号 |
C07K14/47 |
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