This invention relates to a purification method, particularly for purifying tyrosine kinase receptor related polypeptides, and to products made by the method. The method comprises a method of producing tyrosine kinase receptor-related polypeptides, the method comprising expressing a tyrosine kinase receptro-related polypeptide in a recombinant expression system and separating expressed monomeric tyrosine kinase receptor-related polypeptide from multimeric form(s) of the expressed polypeptide in a separation step, the separation step allowing refolding of the expressed tyrosine kinase receptor-related polypeptide into a biologically active form.
申请公布号
WO03025016(A3)
申请公布日期
2003.07.03
申请号
WO2002GB04214
申请日期
2002.09.17
申请人
THE UNIVERSITY OF BRISTOL;DAWBARN, DAVID;ALLEN, SHELLEY, JANE;ROBERTSON, ALAN, GEORGE, SIMPSON