发明名称 |
PYRAZOLE-AMIDES AND-SULFONAMIDES |
摘要 |
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazole-amides and -sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularl y pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
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申请公布号 |
CA2465207(A1) |
申请公布日期 |
2003.05.08 |
申请号 |
CA20022465207 |
申请日期 |
2002.11.01 |
申请人 |
ICAGEN, INC. |
发明人 |
GROSS, MICHAEL FRANCIS;ATKINSON, ROBERT NELSON |
分类号 |
A61K31/4152;A61K31/416;A61K31/454;A61K31/55;C07D231/14;C07D231/40;C07D401/12;C07D403/12;C07D405/12;C07D409/12;C07D413/12;C07D417/12;C07F5/02;(IPC1-7):C07D231/10;A61K31/415 |
主分类号 |
A61K31/4152 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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