MIXTURES OF DRUG-OLIGOMER CONJUGATES COMPRISING POLYALKYLENE GLYCOL, USES THEREOF, AND METHODS OF MAKING SAME
摘要
A non-polydispersed mixture of conjugates in which each conjugate in the mixture comprises a drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may result in less inter-subject variability than polydispersed mixtures of similar conjugates.
申请公布号
WO02098446(A1)
申请公布日期
2002.12.12
申请号
WO2002US17567
申请日期
2002.06.04
申请人
NOBEX CORPORATION;EKWURIBE, NNOCHIRI, N.;PRICE, CHRISTOPHER, H.;ANSARI, ASLAM, M.;ODENBAUGH, AMY, L.
发明人
EKWURIBE, NNOCHIRI, N.;PRICE, CHRISTOPHER, H.;ANSARI, ASLAM, M.;ODENBAUGH, AMY, L.