发明名称 Adjuvant immune therapy in the treatment of solid tumors through modulation of signaling pathways following engagement of humoral and cell mediated responses
摘要 The invention combines a novel combination with two especially important aspects: first, the invention proposes to simultaneously stimulate response in white blood cells and a patient's tumor cells with a mitogen-challenging compound, preferably a lectin, in the preferred mode the selected lectin being phytohemagglutin ("PHA"), and second, to generate heat shock protein. A method of treatment is set out. The method of manufacturing proposed utilizes a system calculated to better insure sterility and streamline production of the cytokine modulator. A method of testing in conjunction with the therapy is also claimed utilizing clinical assessment of disease activity, patient performance status, and quality of life questionnaire. Should efficacy of a treatment fall off, particularly because of mutation or adaption, the composition and method may be re- applied. The invention is not limited to humans, but is also applicable to mammals. The composition is usable as a stand-alone composition, but preferably is used in conjunction with standard therapy such as radiation, chemotherapy or surgery, particularly surgical therapy, and in conjunction with the administration of cystine, as later defined, to enhance immune system competency.
申请公布号 US2002187130(A1) 申请公布日期 2002.12.12
申请号 US20010880745 申请日期 2001.06.13
申请人 KINDNESS GEORGE;SCHUMM BROOKE;GUILFORD F. TIMOTHY 发明人 KINDNESS GEORGE;SCHUMM BROOKE;GUILFORD F. TIMOTHY
分类号 A61K31/198;A61K31/22;A61K31/365;A61K31/366;A61K31/415;A61K45/06;(IPC1-7):A61K45/00;A61K38/16 主分类号 A61K31/198
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