发明名称 |
(hydroxyethyl)ureas as inhibitors of alzheimer's beta-amyloid production |
摘要 |
Novel (hydroxyethyl)ureas are described. These compounds are effective inhibitors of certain aspartyl proteases, notably secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-beta peptide. Methods are provided for administering the novel compounds to treat beta-amyloid-associated diseases, notably Alzheimer's disease. |
申请公布号 |
AU8125001(A) |
申请公布日期 |
2002.02.25 |
申请号 |
AU20010081250 |
申请日期 |
2001.08.10 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
MICHAEL S. WOLFE;DENNIS J. SELKOE |
分类号 |
A61K31/17;A61K31/223;A61K31/47;C07C275/24 |
主分类号 |
A61K31/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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