ANTI-AMYLOIDOGENIC AGENTS

摘要

A method for treating a human amyloid disease which includes administering a pharmaceutically effective amount of a composition to form an amyloidogenic protein-stabilizing aryl compound. These compounds include an amyloidogenic protein-stabilizing compound; said amyloidogenic protein-stabilizing compound is a nonsteroidal anti-inflammatory compound selected from 2,4,6-triiodophenol, mefenamic acid, diflunisal, meclofenamic acid, milrinone, ethacrynic acid, diclofenac, indomethacin, sulindac, fenclofenac, fenoprofen, flufenamic acid, and EMD 21388 (Merck), (i.e., 2-(3,5-dibromo-4-hydroxyphenyl)-4H-6-hydroxy-1-benzopyran-4-one see structure (I)).