| 发明名称 |
ATTENUATED MICROORGANISMS FOR THE TREATMENT OF INFECTION |
| 摘要 |
A <i>Salmonella</i> microorganism has an attenuating mutation which disrupts the expression of an apparatus gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response.
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| 申请公布号 |
WO0068261(A3) |
申请公布日期 |
2001.02.08 |
| 申请号 |
WO2000GB01749 |
申请日期 |
2000.05.09 |
| 申请人 |
MICROSCIENCE LIMITED |
发明人 |
DOUGAN, GORDON;SANTANGELO, JOSEPH, DAVID;HOLDEN, DAVID, WILLIAM;SHEA, JACQUELINE, ELIZABETH;HINDLE, ZOE |
| 分类号 |
C12N15/09;A61K35/74;A61K39/112;A61K48/00;A61P31/04;A61P43/00;C07K14/255;C12N1/21;C12N15/31;C12R1/42;(IPC1-7):C07K14/255 |
主分类号 |
C12N15/09 |
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