发明名称 Method of locking 1alpha-oh of vitamin d compounds in axial orientation
摘要 A method of modifying or altering the structured a 1alpha-hydroxylated vitamin D compound to increase its biological activity by altering the conformational equilibrium of the A-ring to favor a chair conformation that presents the 1alpha-hydroxyl in the axial orientation. This is accomplished by either locking the A-ring chair conformation in a geometry having an axially orientated 1alpha-hydroxyl, or by the addition of one or more substituents to the A-ring which interact with other substituents in the molecule or on the A-ring to provide a driving force to the A-ring to adopt a chair conformation which presents the 1alpha-hydroxyl in the axial orientation.
申请公布号 AU3075499(A) 申请公布日期 1999.12.06
申请号 AU19990030754 申请日期 1999.03.10
申请人 WISCONSIN ALUMNI RESEARCH FOUNDATION. 发明人 HECTOR F. DELUCA;RAFAL R. SICINSKI
分类号 A61K31/59;A01N43/02;A01N43/08;A01N43/16;A01N43/26;A01N43/30;A01N45/00;A61K31/335;A61P3/10;A61P5/14;A61P5/18;A61P7/00;A61P9/12;A61P11/06;A61P17/00;A61P17/06;A61P17/10;A61P17/14;A61P19/08;A61P19/10;A61P25/00;A61P29/00;A61P35/00;A61P35/02;A61P37/06;C07C;C07C401/00;C07C403/00;C07D305/00;C07D311/04;C07D321/00 主分类号 A61K31/59
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