Peripherally active anti-hyperalgesic opiates

摘要

Compositions and methods using the compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors, but that do not, upon topical or local administration, elicit substantial central nervous system effects. The anti-diarrheal compound 4-(p-chlorophenyl)-4-hydroxy-N-N-dimethyl- alpha , alpha -diphenyl-1-piperidinebutyramide hydrochloride is preferred for use in the compositions and methods.