ARYL (SULFIDE, SULFOXIDE AND SULFONE) DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

摘要

Novel aryl (sulfide, sulfoxide and sulfone) derivatives represented by general formula (I) or salts thereof; and drugs containing the same as the active ingredient wherein R1 represents H or alkyl; R2 represents COOR7 or CONHOR8; E represents -CONR?9-, -NR9¿CO-, -OCO-, -COO-, -CH¿2?-O-, -(CH2)2-, vinylene or ethynylene; J represents a single bond or alkylene; A represents H, alkyl, Ar or alkyl -OH; R?3 and R4¿ represent each H, alkyl, COOR19, hydroxy, -NR20R21, (a), Ar1, etc.; and R?5 and R6¿ represent each H or methyl. These compounds inhibit matrix metalloproteinases and are useful in preventing and/or treating various diseases such as rheumatism, osteoarthritis, pathologic bone resorption, osteoporosis, periodontal diseases, interstitial nephritis, arteriosclerosis, pulmonary emphysema, hepatic cirrhosis, corneal injury, autoimmune diseases, diseases caused by the liberation or infiltration of leukocytic cells into blood vessels, and neovascularization.