MACROMOLECULAR PARAMAGNETIC COMPOUND, METHOD OF SYNTHESIS OF MACROMOLECULAR PARAMAGNETIC COMPOUND, DIAGNOSTIC CONTRASTING AGENT, METHOD OF DIAGNOSTIC CONTRASTING AGENT PREPARING

摘要

There are provided paramagnetic compounds comprising a paramagnetic metal species chelated by a chelating moiety bound by an amide group to a linker group itself bound by an ester group to a macromolecule, wherein said linker group provides a carbon chain of at least 2 atoms between said amide group and said ester group. The novel compounds are particularly suitable as contrast agents, e.g. in magnetic resonance imaging.