IMPROVED PHARMACEUTICAL COMPOSITIONS FOR GENE THERAPY

摘要

The invention is based on the discovery of a synthetic virus like particle containing a plurality of peptides capable of condensing nucleic acid and condensed nucleic acid. The plurality of peptides has a low polydispersion index and each peptide of said plurailty is a heteropeptide. The nucleic acid may encode sequences of therapeutic benefit. The synthetic virus like particle is self-assembling and may be designed so as to be capable of targeting a particular cell or tissue type and delivering nucleic acid to be incorporated into the chromosomal or extrachromosomal sequences of the target cells or tissues.