Chrysospermins, active peptides from apiocrea chrysosperma having a pharmacological effect and a use thereof

摘要

The invention relates to the chrysospermin active peptides of the formula I AcPhe-Aib-Ser-Aib-x-Leu-Gln-Gly-Aib-Aib-Ala-Ala-Aib-Pro- y-Aib-Aib-Gln-Trp-ol (SEQ ID NO. 1) in which x and y, independently of each other, denote Aib or Iva, which are synthesized by the fungus Apiocrea chrysosperma during fermentation and which accumulate in the culture broth, to a preparation process, to the use of the chrysospermins as pharmacological active compounds, in particular as active compounds against bacteria, fungi and/or nematodes, and for the treatment of rejection reactions in organ transplantations and of tumor disorders, and to the microorganism Apiocrea chrysosperma DSM 7444.