摘要 |
PURPOSE:To obtain the subject compound useful as a synthetic intermediate for optically active diol efficiently in high yield by allowing a living tissue to act on a specific enantiomer mixture to effect stereoselective hydrolysis of the cyclic carbonate ester site to leave only its antipode. CONSTITUTION:A living tissue or microbial cells containing an esterase or the esterase are allowed to act on an enantiomer mixture of 4-methyl-1,3- dioxane-2-one of the formula [(n) is 1, 2; R is 1 to 11C alkyl, halogenated alkyl, 1 to 11C alkenyl, (hetero atoms-containing) aryl] to effect stereoselective hydrolysis of the cyclic carbonate ester site to leave only its antipode whereby the objective compound is obtained. |