1-amino thiorcyl benzimidazoyl-2-one compounds

摘要

This invention relates to 1-amino thioacylbenzimidazoyl-2-one derivatives having the formula: <IMAGE> wherein R1, R2 and R3 are defined herein. These compounds are useful as thioacylating reagents. This invention also relates to a process for producing cyclic and linear thiopeptides using the thioacylating reagents of this invention. This invention further relates to intermediate anilide compounds, which are produced by reacting an ortho phenylene diamine with an amino acid chain or peptide. This invention also relates to intermediate thioanilide compounds, which are produced by thionating the intermediate anilide compounds. This invention further relates to a process for producing the thioacylating reagents of this invention by cyclizing the intermediate thioanilide compounds.