发明名称 |
INHIBITION OF INTIMAL HYPERPLASIA USING ANTIBODIES TO PDGF RECEPTORS |
摘要 |
Methods of inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal an anti-PDGF receptor antibody, such as an anti-PDGF-alpha receptor antibody or an anti-PDGF-beta receptor antibody. The methods are useful in reducing intimal hyperplasia due to, for example, vascular injuries resulting from angioplasty, endarterectomy, reduction atherectomy or anastomosis of a vascular graft. |
申请公布号 |
WO9419016(A1) |
申请公布日期 |
1994.09.01 |
申请号 |
WO1994US01611 |
申请日期 |
1994.02.17 |
申请人 |
ZYMOGENETICS, INC.;UNIVERSITY OF WASHINGTON |
发明人 |
HART, CHARLES, E.;KENAGY, RICHARD, D.;CLOWES, ALEXANDER, W. |
分类号 |
C12N15/09;A61K31/00;A61K38/00;A61K39/395;A61P7/00;A61P9/00;A61P43/00;C07K16/22;C07K16/28;C12N15/02;C12P21/08;C12R1/91;(IPC1-7):A61K39/395 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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