发明名称 CROSS-LINKED POLYHYDROXYLIC MATERIAL FOR ENZYMATICALLY CONTROLLED DRUG RELEASE
摘要 <p>The present application is concerned with a solid slow release pharmaceutical dosage unit. More specifically, the invention is directed to a tablet form prepared by direct compression of cross-linked amylose (CLA) having a definite cross-linking degree, α-amylase and a pharmaceutical agent. The presence of the cross-linked amylose allows a sustained release of the drug, while the α-amylase permits the modulation of the release time. In other words, the release time of the drug is function of the amount of α-amylase in the tablet. The amount of α-amylase is defined in terms of Enzyme Units.</p>
申请公布号 WO1994002121(A1) 申请公布日期 1994.02.03
申请号 CA1993000298 申请日期 1993.07.22
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