| 摘要 |
<p>The invention relates to a method for stabilizing the hybridization of a first DNA or RNA polynucleotide sequence, modified or not, with an anomeric configuration α or β by means of a second target sequence complementary of the first DNA or RNA sequence, characterized in that a peptide optionally fixed to said first sequence is complexed on the double hybridization helix formed by said first and second nucleotide sequences. The present invention also relates to peptide-polynucleotide conjugates useful for the method, as well as their application as diagnostic probes or as therapeutic agents, in particular.</p> |
