| 摘要 |
<p>NEW MATERIAL:A compound shown by formula I (R1-R4 are H, hydroxyl, 16C alkyl, 2-6C alkenyl, etc.; 1-6C aminoalkyl which may contain protecting group or 1-6C alkyl or heterocyclic group which may contain 1-6C alkyl, amino, halogen or cyano, etc.). EXAMPLE:4-Amino-4,11-diethyl-9-methoxy-1H-pyrano[3',4':6,7]indolizino[ 1,2- b]quiuolin-3,14(4H,12H)-dione. USE:An antitumor agent. PREPARATION:An aminoketone compound shown by formula II is condensed with a pyranoindolizine compound shown by formula III by Friedelaer's reaction and when azido group is contained, catalytic hydrogenation is carried out. The reaction, for example, is carried out in the presence of an acid such as p-toluenesulfonic acid or a base such as potassium carbonate in a solvent such as benzene.</p> |
