发明名称 |
Analogues of pyrrolo[3,2d]pyrimidin-4-ones |
摘要 |
The present invention is novel derivatives of pyrrolo[3,2-d]pyrimidines and pharmaceutical compositions and methods of use therefor. The derivatives are inhibitors of purine nucleoside phosphorylase selectively cytotoxic to T-cells but not to B-cells in the presence of 2'-deoxyguanosine and, therefore, are for use in the treatment of autoimmune diseases, gout, psoriasis or rejection of transplantation.
|
申请公布号 |
US4923872(A) |
申请公布日期 |
1990.05.08 |
申请号 |
US19890336585 |
申请日期 |
1989.04.10 |
申请人 |
WARNER-LAMBERT CO. |
发明人 |
KOSTLAN, CATHERINE R.;SIRCAR, JAGADISH C. |
分类号 |
C07D239/46;C07D405/06;C07D409/06;C07D487/04 |
主分类号 |
C07D239/46 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|