发明名称 Procedure for preparing a protein labelled with a metallic radionuclide
摘要 Procedure for preparing a protein labelled with a metallic radionuclide. It involves reacting a protein with an agent to bind the radionuclide to the protein, thus forming a protein conjugate, and then complexing the radionuclide with a conjugate so formed in order to form a radionuclide complex. The binding agent consists of a thio compound of the formula Y-R-S-X, in which X, R and Y are defined as in the description, or of a cyclic condensation product of said thio compound. The protein so labelled can be used for diagnostic or therapeutic purposes in the treatment of tumours.
申请公布号 ES2013046(A6) 申请公布日期 1990.04.16
申请号 ES19890000646 申请日期 1989.02.22
申请人 MALLINCKRODT, INC. 发明人 GOEDEMANS WILHEMUS T;PANEK KAREL J.
分类号 G01N33/534;A61K38/00;A61K39/395;A61K51/00;C07D333/36;C07D335/02;C07K1/00;C07K1/113;C07K14/00;C07K14/76;C07K16/00;(IPC1-7):C07K3/00;A61K49/02 主分类号 G01N33/534
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