Immobilization of peptide-containing compounds on metal hydroxide gels

摘要

Peptide-containing compounds such as enzymes, antibodies and antigens are immobilized on metal hydroxy gels formed by hydrolysis of metal alkoxides in an aqueous solvent while evaporating off the solvent. Preferably, hydrogen fluoride is present in the solvent during hydrolysis to provide a fluoride-substituted metal hydroxy gel. Water containing lower alcohol is a preferred solvent. The gel is treated with a coupling agent and a peptide-containing compound is chemically bonded to the gel.