摘要 |
1,3-Disubstituted piperidine compounds of the formula
<CHEM>
and the pharmaceutically-acceptable acid-addition salts thereof; wherein
X and Y are each hydrogen, fluoro, chloro or bromo;
Z is hydrogen, fluoro or chloro;
Q represents a chemical bond, a divalent group of the formula -C(=O)- or a divalent group of the formula -CH(OH)-;
and n is an integer from 3 to 5.
<??>The compounds possess pharmaceutical activity as neuroleptic agents, and they are useful for treating psychotic disorders, e.g. schizophrenia, in human subjects. In particular, they are useful for alleviating such symptoms as anxiety, agitation, excessive aggression, tension and social or emotional withdrawal in psychotic patients.
<??>Certain 3-(3-methoxyphenyl)-piperidine compounds are useful as chemical intermediates to the aforementioned neuroleptic agents are also described. |