PROCESS FOR PRODUCING CRYSTALLINE SALTS OF SQUARE BRACKETS OPEN 3 S/Z SQUARE BRACKETS CLOSED-2- BRACKETS OPEN SQUARE BRACKETS OPEN SQUARE BRACKETS OPEN 1-(2-AMINO-4-THIA-ZOLYL)-2- SQUARE BRACKETS OPEN SQUARE BRACKETS OPEN 2,2-DIMETHYL-4-OXO-1-SULFOXY-3-AZETIDINYL SQUARE BRACKETS CLOSED -AMINO SQUARE BRACKETS CLOSED -2-OXO-ETHYLIDENE SQUARE BRACKETS CLOSED -AMINO SQUARE BRACKETS CLOSED -OXY BRACKETS CLOSED ACETIC ACID AND PHARMACEUTICS COMPRISING SAME AS ACTIVE INGREDIENT

摘要

In accordance with the present invention an orally active monosulfactam antibiotics having a crystalline structure and thereby improved stability are disclosed. The antibiotics comprise the dierythromycin (M(+)=erythromycin.H(+)) salt or the dicholine (M(+)=HOCH2CH2N(+)(CH3)3) salt of the acid (M(+)=H(+)) having the formula that is, [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy )-3-azetidinyl]-amino]-2-oxoethylidene]amino]oxy]acetic acid.