发明名称 |
Process and composition for amino-terminal, alpha -aspartyl and alpha -glutamyl dipeptide esters |
摘要 |
Reaction of a ketoxime-derivatized resin with a strong acid salt of aspartic anhydride or glutamic anhydride yields a novel aspartyl or glutamyl ketoxime ester-derivatized resin, wherein the aspartyl or glutamyl groups are esterified predominantly at the alpha -carboxyl group and wherein the aspartyl or glutamyl groups are not covalently protected at the amino group or the carboxyl group that is not esterified. Aminolysis in the presence of a weak acid of the novel aspartyl or glutamyl ketoxime ester-derivatized resin, wherein the aspartyl or glutamyl groups remain as the strong acid salt, with a salt of an amino acid with a base or an amino acid ester yields the corresponding dipeptide or dipeptide ester. After aminoylsis, the ketoxime-derivatized resin can be reused. An advantageous solid-phase method is thus provided for making alpha -L-aspartyl dipeptide ester sweeteners, including aspartame, and the immunopotentiating dipeptide, alpha -L-glutamyl-L-asparagine.
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申请公布号 |
US4731412(A) |
申请公布日期 |
1988.03.15 |
申请号 |
US19860851444 |
申请日期 |
1986.04.14 |
申请人 |
THE SALK INSTITUTE BIOTECHNOLOGY/INDUSTRIAL ASSOCIATES, INC. |
发明人 |
KAISER, EMIL T.;MUSSO, GARY F. |
分类号 |
C07K5/072;(IPC1-7):C08F8/32 |
主分类号 |
C07K5/072 |
代理机构 |
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地址 |
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