| 摘要 |
PURPOSE:A composition useful as a base for cream agent or a cream agent, having improved emulsion stability, feeling in use and endermic absorption characteristics of drug, obtained by blending a hydrocarbon with a higher alcohol, a nonionic surface active agent of ether type, water and urea. CONSTITUTION:(A) 1-50wt% hydrocarbon such as white vaseline or liquid paraffin is blended with (B) 2-20wt% higher alcohol, preferably cetanol or stearyl alcohol, (C) 0.5-10wt% nonionic surface active agent of ether type, preferably having 10-20 HLB value, such as POE(20) cetyl ether, (D) 50-80wt% water and (E) 1-30wt% urea. The urea blended has stability, especially heat stability, the composition is storable for a long period, rapidly varnishes owing to a large amount of water added and has either shining nor greasiness. The composition is useful as a cream agent for remedying skin diseases and also as a cream agent base for raising stability and endermic absorption properties of drug blended.
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