Process for preparing 2-[(N-2-pyridylcarbomyl)methyl]saccharin

摘要

Process for preparing 2-[(N-2-pyridylcarbomyl)methyl]saccharin of the formula <IMAGE> (IX) using 1-methyl-2-chloropyridine-iodine as the condensing agent. The process involves reacting a mixture of 2-aminopyridine, tri-n-butylamine and 2-carboxymethyl saccharin (VIII), in dichloromethane, in the presence of 1-methyl-2-chloropyridine iodine (X).