| 摘要 |
PURPOSE:To obtain the titled compound utilizable in fields of food, agriculture, medicines, etc. from an easily available raw material by a simple method, by reacting an allylglycine derivative with a diazo compound in the presence of a metal catalyst. CONSTITUTION:An allylglycine derivative expressed by formula I (R<4> is a protecting group of NH2; R<5> is lower alkyl or aralkyl) is dissolved in an ether based or (chlorinated) hydrocarbon based solvent, and an azo compound expressed by formula II (R is H, lower alkyl or lower alkoxycarbonyl) is added thereto and reacted therewith in the presence of a metal catalyst, e.g. palladium acetate or rhodium chloride, at 0-30 deg.C. After completing the reaction, the hydrolysis or removal of the protecting group or both are carried out if necessary to afford the aimed compound expressed by formula III (R<1> is H, alkyl, carboxyl or lower alkoxycarbonyl; R<2> is H or R<4>; R<3> is H or R<5>). |
