| 发明名称 |
COMPOSITIONS AND METHODS FOR SENSITIZING AND INHIBITING GROWTH OF HUMAN TUMOR CELLS |
| 摘要 |
Polynucleotides encoding a carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a chemotherapeutic prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing tumor cells to a prodrug chemotherapeutic agent and inhibiting tumor growth with this enzyme are also provided. In addition, screening assay for identification of drugs activated by this enzyme are described.
|
| 申请公布号 |
CA2320808(A1) |
申请公布日期 |
1999.08.26 |
| 申请号 |
CA19992320808 |
申请日期 |
1999.02.12 |
| 申请人 |
ST. JUDE CHILDREN'S RESEARCH HOSPITAL |
发明人 |
HOUGHTON, PETER J.;POTTER, PHILIP M.;DANKS, MARY K. |
| 分类号 |
G01N33/50;A61K31/4745;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P35/00;C07H21/04;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/18;C12N15/09;C12N15/55;C12N15/63;C12N15/85;C12Q1/44;G01N33/15;(IPC1-7):C12N15/55;C12Q1/68 |
主分类号 |
G01N33/50 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
